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      產(chǎn)品中心

      NFkB p65 Mouse mAb
      EM1111
      規(guī)格: 價(jià)格:
      50μL ¥1280.00
      100μL ¥1980.00

      Overview 文獻(xiàn)

      Product name: NFkB p65 Mouse mAb
      Reactivity: Human, Rat, Mouse
      Alternative Names: NFKB3, p65, RELA, Transcription factor p65
      Source: Mouse
      Dilutions: WB 1:500-2,000 IP 1:200 IF 1:100-200 IHC 1:200-500
      Immunogen: Recombinant Protein
      Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles.
      Clonality: Monoclonal
      Isotype: IgG1
      Concentration: 1mg/mL
      Observed Band: 65kDa
      GeneID: 5970
      Human Swiss-Prot No: Q04206
      Cellular localization: Cytoplasm,?Nucleus
      Background: NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection.
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